In the realm of maternal-fetal medicine, hydroxychloroquine 200 mg has garnered attention for its role in managing autoimmune diseases during pregnancy. Pregnant individuals with conditions such as lupus or antiphospholipid syndrome face unique challenges due to the potential impact of their autoimmune condition on maternal and fetal health. Plaquenil is often used as a maintenance therapy during pregnancy, as it is considered safer than some alternative medications. Its ability to control disease activity while minimizing adverse effects on the developing fetus makes it a valuable option for pregnant individuals with autoimmune diseases, highlighting the importance of comprehensive prenatal care and multidisciplinary management.